![]() Made it with a mix of blackberries, blueberries, and blackcurrants. I actually screwed up and only used 2 egg yolks in custard instead of 4 and couldn't figure out why it was so thick? Then I realized what I did and put the custard with 1/2c heavy cream in my mixer and whipped it until smooth and fluffy! My fault! But I saved the tart! Will make again with FOUR yolks next time! Loved the crust! I make frangipane ie: almond cream tarts all the time so this was a nice change light and fluffy! Keep chilled.Īdded 1/4 tsp almond extract to custard. Step 11ĭo Ahead: Custard can be made 4 days ahead. Vigorously whisk cooled custard until smooth and slightly loosened. Transfer to a medium bowl and cover with plastic wrap, pressing directly against surface of cream. Add butter a couple of pieces at a time, whisking until fully melted before adding more, until all butter is incorporated. Heat over medium and bring to a simmer, whisking constantly, until mixture is bubbling and thick with no cornstarch taste, about 3 minutes. Then vigorously whisk until mixture lightens in color to a very pale yellow and is very thick, about 1 minute (the sugar should be nearly dissolved). Meanwhile, whisk egg yolks, sugar, cornstarch, and salt in a medium bowl (start slowly-it won’t want to combine easily at first). Wrap very tightly with plastic and store at room temperature.īring milk and vanilla paste to a simmer in a medium saucepan over medium-high heat. Step 7ĭo Ahead: Crust can be baked 2 days ahead. Step 6īake crust until deep golden brown all over, 35–40 minutes. Press dough into bottom and 1" up sides of a 9" springform pan or a 9" tart mold. Repeat several times until dough is well combined and becomes slightly sticky. Divide dough in half, stack 1 piece on top of the other, then press down firmly to smash both dough pieces together. Turn dough out onto a work surface and knead 1 or 2 more times. Knead dough in bowl with your hands until it starts to come together (it will still look a little dry if it looks too dry and doesn't come together, add 1–2 Tbsp. ![]() Using a fork or your fingertips, toss egg yolk mixture into dough to combine. ![]() Rub butter into dry ingredients with your fingertips to create large, shaggy pieces of dough (the idea is to smash the butter into the flour, creating some pieces that are flat and thin and some that are large and irregular). Whisk all-purpose flour, almond flour, sugar, and salt in a medium bowl.
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Our experts have been helping you master your money for over four decades. So, whether you’re reading an article or a review, you can trust that you’re getting credible and dependable information. Our editorial team receives no direct compensation from advertisers, and our content is thoroughly fact-checked to ensure accuracy. ![]() ![]() We follow strict guidelines to ensure that our editorial content is not influenced by advertisers. Our goal is to give you the best advice to help you make smart personal finance decisions. Our editorial team does not receive direct compensation from our advertisers.īankrate’s editorial team writes on behalf of YOU - the reader. We maintain a firewall between our advertisers and our editorial team. Our editors and reporters thoroughly fact-check editorial content to ensure the information you’re reading is accurate. 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The offers that appear on this site are from companies that compensate us. ![]() Our goal is to help you make smarter financial decisions by providing you with interactive tools and financial calculators, publishing original and objective content, by enabling you to conduct research and compare information for free - so that you can make financial decisions with confidence.īankrate has partnerships with issuers including, but not limited to, American Express, Bank of America, Capital One, Chase, Citi and Discover. We are an independent, advertising-supported comparison service. Here we demonstrate that LIG1 is a highly accurate DNA ligase in vivo. However, despite the importance of DNA ligation reactions for life, whether high-fidelity DNA ligation is required for faithful DNA replication in vivo remains unknown. Mutation of two highly conserved Mg 2+-binding glutamic acid residues in LIG1 that form this interface to alanines reduces enzyme accuracy but does not impact enzymatic turnover, thereby facilitating mutagenic ligation 14. The interface formed between LIG1, Mg 2+, and the DNA substrate is critical for ensuring that DNA nicks containing damaged or mutagenic ends are not sealed, thereby promoting high-fidelity DNA ligation. A recently published high-resolution structure of LIG1 bound to a nicked DNA duplex reveals that it employs a Mg 2+-reinforced DNA-binding mode to promote high-fidelity DNA ligation in vitro 14. Successful OFM produces undamaged DNA ends that are sealed by LIG1 to ensure faithful DNA replication and avoid genome instability in the form of DNA breaks, deletions, and duplications.Īmong four known eukaryotic DNA ligases 11, 12, 13, LIG1 is the enzyme involved in OFM. The resulting nick is then sealed by DNA ligase 1 (LIG1) to finalize synthesis of the DNA strand. This occurs by nick-translation/strand displacement DNA synthesis catalyzed by Pol δ to create DNA substrates that are cleaved by Fen1 and/or by DNA2 nucleases 5, 6, 7, 8, 9, 10. Okazaki fragment processing involves replacement of RNA–DNA primers made by Pol α-primase. Second only to this selectivity is proper Okazaki fragment maturation (OFM) of lagging strand DNA fragments, an event that occurs thousands to millions of times during each DNA replication cycle in eukaryotic cells 2, 3, 4. The most abundant DNA transaction in eukaryotic cells that affects the fidelity of nuclear DNA replication is the nucleotide selectivity of DNA polymerases (Pols) α, δ, and ε during incorporation into a growing DNA chain during leading and lagging strand synthesis 1. Collectively, our data indicate that high-fidelity DNA ligation is required to prevent insertion mutations, and that this may be particularly critical following strand displacement synthesis during the completion of OFM. ![]() ![]() Biochemical and structural data establish that LIG1 Cdc9 normally avoids erroneous ligation of DNA polymerase slippage products, and this protection is compromised by mutation of a LIG1 Cdc9 high-fidelity metal binding site. The rate at which these additions are generated increases upon concomitant inactivation of DNA mismatch repair, or by inactivation of the Fen1 Rad27 Okazaki fragment maturation (OFM) nuclease. Here, we show that an engineered low-fidelity LIG1 Cdc9 variant confers a novel mutator phenotype in yeast typified by the accumulation of single base insertion mutations in homonucleotide runs. Whether intrinsic ligation fidelity contributes to the accuracy of replication of the nuclear genome is unknown. DNA ligase 1 (LIG1, Cdc9 in yeast) finalizes eukaryotic nuclear DNA replication by sealing Okazaki fragments using DNA end-joining reactions that strongly discriminate against incorrectly paired DNA substrates. ![]() In the cult favorite Sparkle (1976), the Harlem-set rags-to-riches story inspired by The Supremes, Alice was memorable as Effie, the single mom raising daughters played by Irene Cara, Lonette McKee and Dwan Smith. ![]() She also played dorm director Lettie Bostic in 1988-89 on the first two seasons of NBC’s A Different World the mother of Oprah Winfrey‘s Mattie Michael in 1989 on the ABC miniseries The Women of Brewster Place and the mother of Harold Perrineau Jr.’s Augustus Hill in 2002 on HBO’s Oz. The onetime Chicago schoolteacher received back-to-back Emmy nominations in 1992 and ’93 - winning in the second year - for her supporting turn as Marguerite Peck, whose child is murdered, on the Atlanta-set NBC legal drama I’ll Fly Away, starring Sam Waterston and Regina Taylor. Matthew Perry Died From Acute Effects of Ketamine, Autopsy Reveals In 1990 films, Alice played Nurse Margaret opposite Robin Williams and Robert De Niro in Awakenings, directed by Penny Marshall the family matriarch dealing with a disruptive guest ( Danny Glover) in Charles Burnett’s To Sleep With Anger and a woman whose son was struck by a car in the South Bronx in Brian De Palma‘s The Bonfire of the Vanities. She was 85.Īlice died Wednesday in her Manhattan apartment, an NYPD spokesperson told The Hollywood Reporter.
The atomic number (expressed by the letter Z) of an element is the number of protons in the nucleus of each atom of that element. Objects, like asteriods or meteors, might have very different isotope quantities. The relative atomic masses specified in periodic table entries-for example, hydrogen-are calculated for all the naturally occurring isotopes of every element, weighted by the quantity of those isotopes on earth. The relative atomic mass is an average of all the atomic masses of different isotopes in a given sample, with each isotope's contribution to the average. Since an element’s isotope differs in its atomic masses, scientists may also establish the relative atomic mass at times called the atomic weight for an element. All isotopes of a particular element have exactly the same number of protons but again only differ in the number of neutrons in each atom. In general, an atom's atomic mass will be very close to its mass number but will have some difference in the decimal places.Īn isotope of an element is a variant of that particular element that consists of a difference in the number of neutrons and further in the nucleon number. By definition, an atom of carbon with 6 neutrons, carbon-12, has an atomic mass of 12 amu. The atomic mass of a single atom is basically its total mass and is usually expressed in atomic mass units or amu. ![]() The notation of an atom is given below.Ī property strongly related to an atom’s mass number is its atomic mass. If you want to calculate the number of neutrons in an atom, you can simply deduct the number of protons, or atomic numbers, from the mass number. Mass Number = Number of protons + Number of neutrons Together, the number of protons and the number of neutrons dictates an element’s mass number. On the other hand, the number of neutrons for a given element can differ. The atomic number is the number of protons there in an atom. In fact, the number of protons dictates what atom we are looking at (e.g., all atoms with 6 protons are carbon atoms). Here, we will discuss important concepts of atomic number and atomic mass.Ītomic Number, Atomic Mass, and Relative Atomic MassĪtoms of each element consist of a particular number of protons. The atomic number and mass number are the basic concepts of atomic structure. ![]() ![]() The mass number is defined as the total number of protons and neutrons of an element. Hence atomic number is useful in differentiating one element from another. No element has an atomic weight less than one.The atomic number is defined as the total number of protons or electrons in an element. One atomic mass unit isĭefined as 1/12 the mass of an atom of carbon-12. ![]() The number in parentheses is the mass number of the most stable or best-known isotope of that element.Ītomic weights are measured in atomic mass units. These elements are unstable that is, their nuclei decompose radioactively. The atomic weight of some elements is given as a whole number enclosed in parentheses. That 75.53% of naturally occurring chlorine is chlorine-35 and 24.47% is chlorine-37. The atomic weight of chlorine (35.45) reflects the fact The atomic weight of carbon (12.01) reflects the relative abundance of The atomic weight of an element is based on the variety of naturally occurring isotopes of that element and the relative abundance of each.Ī collection of naturally occurring carbon atoms contains 98.89% carbon-12Ītoms and 1.11% carbon-13 atoms, along with a trace percentage of carbon-14Ītoms. Both the periodic table and the alphabetical list of the elements show the atomic weights of the elements. The atomic weight (or atomic mass) of an element is the average relative mass of the naturally occurring atoms of that element. ![]() Does free food come with the Popeyes app? ![]() You would need to meet certain requirements or follow certain rules to get the 59-cent deal. Popeyes raised the price of their famous fried chicken by 59 cents on certain days of the week. The Louisiana-style fried chicken that Popeyes is known for is what made it a popular name. Most people know Popeyes for its tasty and crispy fried chicken. Use it on chicken wings, fries, and everything else. The spice is kept behind the counter and only available if you ask. When you’re checking out, ask the cashier to add a few packets of Cajun Sparkle to your bag. It goes well with everything Popeyes serves. This addictive Cajun spice is by far the easiest thing to order from the secret menu. It’s an easy combination, but the taste is out of this world. Just order biscuits and ask if they can be covered in the cinnamon sugar that Popeyes usually saves for apple pies. Cinnamon Sugar Biscuits:Įven though it’s hard to buy, this one is worth it because it tastes so good. Just get the side with two packets of honey and one packet of hot sauce (or more or less, depending on your taste), pour them in, mix them, and enjoy the tasty combination. This new take on Popeyes’ famous red beans and rice is the most nice surprise on the secret menu. Then I put them together and made this delicious secret menu item well-known among fans of the chain. I asked Popeyes nicely to give me their chicken with a side of cookies. Yes, cooked chicken can be eaten for breakfast. What happened? I didn’t know it was possible, but Popeyes’ signature dish could be made better. Get your chicken burger with a side of ranch, and then drizzle the farm over the chicken. But I’m hooked after hearing about this secret menu version on the web and trying it for myself. The Popeyes Chicken Sandwich has become a well-known fast food treat, so we’re not making a big change here. Popeyes Secret Menu used to serve real Cajun poutine with gravy and cheese curds, but they took it off the menu, so fans have started making the dish themselves in this way. Popeyes Cajun Fries are already famous, but if you order the crispy potatoes with the chain’s renowned house-made gravy, you’ll have something like poutine without the cheese. The Popeyes Secret Menu includes the following items: The things on the secret menu are not on the official menu, but regular customers ready to try something new can get them. The secret menu at Popeyes has a nice selection of off-menu items, unique taste combinations, and special tweaks that will take your eating experience to a whole new level. Even though Popeyes is known for its tasty fried chicken and tasty sides, only those working there know about a secret world of tempting goods. Welcome to Popeyes Secret Menu, a world full of interesting things. A pair of opposition lawmakers appealed to the attorney general to investigate Yair Netanyahu's security needs, saying it was "disgraceful that public funds fuel a culture of women's exploitation." Others piled on. The often combative younger Netanyahu issued a quick apology, saying the remarks did not represent the values he was raised on and were made under the influence of alcohol.īut the fallout was swift. Yair Netanyahu has long drawn criticism for living a life of privilege at taxpayers' expense, hobnobbing with ultra-rich donors and making crude social media posts, all while never holding down a job. The chatter is interrupted by a phone call from Yair's mother, which he screens and apparently doesn't answer. "My dad arranged $20 billion for your dad, and you're whining with me about 400 shekels," he says, referring to money he borrowed in a strip club. Most of the public outcry, however, involves Yair's comments to the third member of his entourage - the son of Israeli tycoon Kobi Maimon - about how the prime minister advanced a controversial gas deal in Parliament that benefited his father. ![]() Adding to the anger was the fact that the salacious outing took place on the eve of the Jewish Sabbath - and was aired just as Netanyahu's government was passing unpopular legislation to curb business on the Sabbath under pressure from ultra-Orthodox Jewish coalition partners. The recording, aired Monday night on Israel's top-rated news broadcast, sparked outrage over its misogynistic content and raised questions over why a state-funded bodyguard and driver were necessary to facilitate such debauchery. Benjamin Netanyahu and his son Yair visit the Wailing Wall in Jerusalem on March 18, 2015. "It's possible the waitresses there go with the flow," he adds. "Speaking of prostitutes, what's open at this hour?" he asks his friends, before they settle on a well-known bistro. ![]() ![]() He is also heard drunkenly bragging about how the prime minister advanced a bill that he appears to believe delivered billions to his friend's father - an embarrassing blow to the premier, who stands accused of accepting a fortune's worth of cigars and champagne from rich supporters.Īt one point, Yair cryptically refers to 400 shekels (about $115) paid to a prostitute. Also install the Desktop development with C++ workload for full C++ support. Benefit from a first-class CMake experience. Use MSBuild with the Microsoft Visual C++ compiler or a 3rd party toolset like CMake with Clang or mingw to build and debug your code right in the IDE. Visual Studio 2022 version 17.6 represents the culmination to date for these big rocks: Level Up Your Productivity. Installs the C++ compiler and other necessary components to develop native extensions for Python. Open a codebase from any environment and get to work right away. Installs tools for web development including HTML, CSS, and JavaScript editing support, along with templates for projects using the Bottle, Flask, and Django frameworks. Once you close VS, an update will immediately start and as a result the icon will also disappear. When there is an update available and you have enabled the 'Update on Close' option, the icon will appear. Installs the Cookiecutter graphical UI to discover templates, input template options, and create projects and files. For Visual Studio 2022, we added an overlay to the VS task bar icon to help you know when VS will update. Also, if a newer version of Python is available than what's shown in the installer, you can install that version separately and Visual Studio will detect it. Visual Studio automatically detects existing Python installations. Anaconda, specifically, is an open data science platform that includes a wide range of pre-installed packages. Each includes the distribution's interpreter, runtime, and libraries. The installer provides a list of workloads that are groups of related options for specific development areas.įor Python, select the Python development workload and select Install:Ĭhoose any combination of the available options, such as 32-bit and 64-bit variants of the Python 2, Python 3, Miniconda, Anaconda2, and Anaconda3 distributions that you plan to work with. ![]() Download Visual Studio Code to experience a redefined code. ![]() For other uses, install Visual Studio Professional or Visual Studio Enterprise. Visual Studio Code is free and available on your favorite platform - Linux, macOS, and Windows. The Community edition is for individual developers, classroom learning, academic research, and open source development. ![]() You can create as many presets as you want. If you want to save your current selection of packages, you can create preset file, it will contain list of selected packages. To add it to Mod Installer, simply put the folder into the same as Mod Installer exe file. ![]() Some mods like Winter Hope County or Libertad mod has own ModifiedFiles directory. If you download a mod and it has extension a3 or a4, move the file to ModifiedFiles directory in Mod Installer: You can also remove all mods by verifying game files in Uplay: This will restore game files to their original state. To uninstall all mods use button on center bottom side Uninstall mods. Updates are optional, but if want to report bug, then make sure you're using latest version. Please, never overwrite old folder with the new one, because there can be changed which can produce bugs. You can also do manual update, simply download new version, extract it and copy SettingsFC.xml file to the new version's folder. Mod Installer has integrated update system (UOTA - Update On The Air), so everytime when there is new version available, orange U button appear on right top corner.Ĭhangelog is always displayed in description area when you hover over the U button. Packages are installed into the game files, so they stay installed until you uninstall them. It isn't required to be running during playing. Once you installed packages, you can close Mod Installer. It's not required to uninstall mods and then install them again, simply click directly on Install. If you will want to change selected packages, then run the Mod Installer again, select packages and again click to Install. For easier enabling, click on "Select packages" above the list.Īfter you select packages, click on the Install button on left bottom corner to install them. This is where you can find list of required packages. ![]() If there are packages which are marked with red X and has red border, it means they can't be enabled together or missing another required package to be enabled. Selected package is marked with ✓ and has colored border. Then return to Mod Installer and go to the game dir and then to bin folder: When the extracting finishes, go to the extracted folder and run the exe file.Īfter you run the Mod Installer, it can ask you about language and selecting game. ZIP file can be extracted even in Windows, so you do not need any extra software. If you download full Resistance or Scavenger or Golden Path mod, then Mod Installer is already included in these mods, so you don't have to download it separately.Īfter you download the zip, extract it anywhere in your PC, for example to desktop. By this you can prevent from situations where something causes crash or is bugged.Īt first download Mod Installer. It's recommended to backup your saves after every gameplay. The Mod Installer is an easy tool for selecting mods (packages) and their installing to the game.īefore using Mod Installer, make sure you have clean, unmodified game files.
![]() I am doing like 5 play throughs at once right now and I am only level 3 on all of em, can’t wait to get to level 6 so I can spec pure lore bard and check out the spell myself. This will allow you to ignore your opponents’ resistance to lightning damage, and any lightning damage that you roll the 1s are changed to 2s. On a hit, the target takes 4d8 lightning damage and half damage on a miss. Of course Larian can and has made many tweaks to 5e mechanics as written. If you take the Elemental Adept feat from the 5e Dungeons & Dragons Player’s Handbook you can choose the damage type of lightning. Lightning Arrow turns the Rangers projectile into a bolt of lightning. As written in 5e lightning arrow was a dex save for half, technically I believe that the spell goes from being concentrated on to cast the instant your arrow/bolt/thrown weapon is sent down range and that ammunition is magically replaced by a lightning bolt. Here we discuss the basic traits, optimizations, and differences between chaos bolt and another similar spell. I believe tempest 6 also gets you an optional knock back on all lightning damage, which is amazing in bg3. Chaos bolt is a very powerful, and sometimes extremely jinxed, 1st-level spell falling under the sorcerer spell list. The big difference between this and your planned build is. ![]() You just go deeper into your most valuable class that gets you the biggest spell slots. Levels 11-12: Cleric 2, going Tempest for your dream of Destructive Wrath on Lightning Bolt. Per 1 Quality: 1 Superior 2 3 4 1 chance to Shock enemies Deals (130-154) of Base Attack Damage. If it can crit (apparently all critical hits are automatically maximized meaning destructive wrath would be wasted) then straight lore bard is better, if not then I am taking bard and cleric to 6 each to get both the magical secrets and a 2nd charge of channeled divinity destructive wrath. Levels 7-10: Druid 5, going Circle of the Land, Mountain for your Lightning Bolt. Projectile Speed: 3260 Requires Level 12 Fires a charged arrow at the target, causing them to be struck by a bolt of lightning which damages nearby enemies. My thinking is that depending on Larian’s implantation of lightning arrow tempest may or may not be necessary. It does hurt to loose an asi by dual-classing 6/6 though. I’m thinking I’ll pick up warcaster and savage attacks for feats, or I may boost charisma to 18. As well as water and a lot of lightning spell access. It’s pretty great bless plus sleep and fairy fire and solid heals. I’m actually doing a tempest lore bard on my current play through with a couple of homies from high school. |
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